Lai 2013.

Methods	Randomised trial
Participants	198 participants with osteoporosis (Intervention 98; control 100) A tertiary hospital osteoporosis clinic Malaysia Year of study: September 2005 to February 2009
Interventions	Participants in the intervention group received a ‘‘pharmaceutical care package’’ which included a one‐to‐one, individualised medication review, education on osteoporosis, risk factors, lifestyle modifications, goals of therapy, side effects and the importance of adherence, at months 0 (baseline), 3, 6 and 12, with monthly follow‐ups by telephone calls in between for the first 6 months, then every 3 months up to month 12. Materials included a booklet and a personalised osteoporosis medication regimen. Duration: 12 months
Outcomes	Quality of Life Questionnaire of the European Foundation for Osteoporosis
Notes	Funding source: This project was funded by the Postgraduate Research Fund P0110/2006B, University of Malaya and the Endocrine Research fund, University of Malaya Conflict of interest: Not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Therefore, participants were first divided into whether they were on alendronate or risedronate, then randomly allocated to the intervention group using the random digits table (98) while the rest were allocated to the control group.
Allocation concealment (selection bias)	Unclear risk	No information about concealment.
Blinding of participants and personnel (performance bias) All Outcomes/Outcome 1	High risk	No blinding of participants. Some potential for bias
Blinding of outcome assessment (detection bias) All Outcomes/Outcome 1	High risk	Quality of life is subjective and therefore categorised as high risk
Incomplete outcome data (attrition bias) All outcomes	Low risk	Between group attrition < 10%.
Selective reporting (reporting bias)	Low risk	All reported
Other bias	Low risk	None