Marques 2013.

Methods	Randomised trial
Participants	58 participants with depression (intervention 31: control 27) Outpatient clinic of Alzira Velano Hospital University of Alfenas, Brazil Year of study: April 2010 to January 2012.
Interventions	Patient Education using Dáder method Intervention group patients were visited approximately every 30 days; the intervals between visits could be shorter according to the patient’s needs. These patients were given verbal and written information about the treatment, and educational lectures about disease and treatment; interventions with the psychiatrist were performed as needed. Frequency: monthly Duration: 3 months
Outcomes	Beck depression Inventory (BDI) Becks Anxiety Inventory (BAI)
Notes	Funding source: Not specified Conflict of interest: None stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	According to the Dáder Method, the patients in the intervention group were visited approximately every 30 days; the intervals between visits could be shorter according to the patient’s needs. These patients were given verbal and written information about the treatment and educational lectures about disease and treatment; interventions with the psychiatrist were performed as needed.
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding of participants and personnel (performance bias) All Outcomes/Outcome 1	High risk	Unblinded pharmacists conducted the intervention and control arm interaction: bias possible
Blinding of outcome assessment (detection bias) All Outcomes/Outcome 1	High risk	Participants unblinded completed self‐report measures. Bias is likely.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Between group attrition < 10%.
Selective reporting (reporting bias)	Low risk	All reported
Other bias	High risk	Only 3 months, seasonality, also numbers differ between table and flow chart