Rubio‐Valera 2012.
| Methods | Randomised trial | |
| Participants | 179 participants with depression (intervention 87: control 92) 13 pharmacies (34 pharmacists) Gavó, a city situated in the province of Barcelona, Spain Year of study: OCtober 2008 to not stated. |
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| Interventions | The intervention consisted of a series of educational interventions focused on improving patients' knowledge of antidepressant medication, including the importance of compliance. Moreover, in patients with a sceptical attitude towards medication, the intervention aimed to reduce stigma, reassure the patient about possible side effects, and stress the importance of following GPs' advice. Number of Interventions: initial visit plus single (?) follow‐up Number of follow‐ups unclear |
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| Outcomes | Mean severity of depression Health‐related Quality of Life |
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| Notes | Funding source: Carlos III Health Institute Grant Conflict of interest: None stated |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Quote: "Randomization was generated at the patient level by a computerized random‐number generator following a permuted block design." |
| Allocation concealment (selection bias) | Low risk | Quote: "To assure the concealment of allocation, every GP receives a set of 10 sequentially numbered, opaque, sealed envelopes containing patient assignment. Envelopes were generated by an external investigator and details of the series are unknown to any of the GPs or pharmacists in the study." |
| Blinding of participants and personnel (performance bias) All Outcomes/Outcome 1 | High risk | Unblinded participants and subjective outcomes |
| Blinding of outcome assessment (detection bias) All Outcomes/Outcome 1 | Low risk | Quote: "Blinding of participants and pharmacists is not possible because of the type of intervention. However, the assessment visits and data analysis are conducted by independent and blinded evaluators" |
| Incomplete outcome data (attrition bias) All outcomes | High risk | Between group attrition >20% Quote: "Only 87 (95%) and 64 (74%) in the control and intervention group, respectively, received the intervention as allocated and were included in the PP analysis." |
| Selective reporting (reporting bias) | Low risk | All major results reported |
| Other bias | Low risk | None |