Wang 2010.
| Methods |
Study design: parallel, individual, RCT Centres: 1, Taiwan Start of enrolment: not reported End of enrolment: not reported Follow‐up: at least 3 months Run‐in period: not reported |
|
| Participants |
Inclusion criteria: "hypertensive pts who had DHF, defined as the presence of HF signs/symptoms, diastolic dysfunction (mitral annular early diastolic velocity (E') < 8 cm/s), and left ventricular (LV) ejection fraction (EF) > 50%" Exclusion criteria: not reported Randomised (N): 36 (19 intervention, 17 control) Withdrawn (N): not reported Lost to follow‐up (N): not reported Analysed (N): not reported Age (years, mean, SD): not reported Sex (% men): not reported Ethnicity (%): not reported Systolic blood pressure not reported Heart rate not reported BMI not reported Serum creatinine not reported B‐type natriuretic peptide not reported NT pro B‐type natriuretic peptide not reported LVEF (%, mean, SD): intervention: 67, 7; control: 66, 7 NYHA class not reported Hypertension not reported Diabetes not reported Atrial fibrillation not reported Hospitalisation for heart failure: not reported Coronary heart disease not reported Stroke not reported Diuretic not reported Digoxin not reported Beta‐blocker not reported ACEI not reported ARB not reported MRA study drug |
|
| Interventions |
Intervention: spironolactone. 50 mg/d Comparator: no treatment control Concomitant medication: not reported |
|
| Outcomes |
Planned: we are not aware of a published protocol or pre‐registered clinical trial registry entry Reported: echo‐parameters, systolic myocardial velocities |
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| Notes | does not contribute outcome data to this review | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | not reported |
| Allocation concealment (selection bias) | Unclear risk | not reported |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | not reported |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | not reported |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | not reported |
| Selective reporting (reporting bias) | Unclear risk | unable to assess |
| Other bias | Unclear risk | funding not reported |