Yuksek 2012.
| Methods |
Study design: parallel, individual, RCT Centres: 1, Turkey Start of enrolment: May 2008 End of enrolment: March 2009 Mean follow‐up: 11 months Run‐in period: not reported |
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| Participants |
Inclusion criteria: "HF symptoms. They were ≥ 50 years old, had EF ≥ 50% and echocardiographic diastolic dysfunction." Exclusion criteria: not reported Randomised (N): 108 (54 intervention, 54 control) Withdrawn (N): for reasons other than death 17 (not reported by arm) Lost to follow‐up (N): 3 (not reported by arm) Analysed (N): not reported Age not reported Sex not reported Ethnicity not reported Systolic blood pressure not reported Heart rate not reported BMI not reported Serum creatinine not reported B‐type natriuretic peptide not reported NT pro B‐type natriuretic peptide not reported LVEF not reported NYHA class not reported Hypertension not reported Diabetes not reported Atrial fibrillation not reported Hospitalisation for heart failure: not reported Coronary heart disease not reported Stroke not reported Diuretic not reported Digoxin not reported Beta‐blocker not reported ACEI study drug ARB not reported MRA not reported |
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| Interventions |
Intervention: perindopril, 10 mg/d Comparator: "standard DHF treatment" Concomitant medication: not reported |
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| Outcomes |
Planned: we are not aware of a published protocol or a pre‐registration in a clinical trial register Reported: T‐proBNP values and echocardiography |
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| Notes | no outcome data of interest | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | randomised, but no details |
| Allocation concealment (selection bias) | Unclear risk | not reported |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | not reported |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | not reported |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | not reported |
| Selective reporting (reporting bias) | Unclear risk | unable to assess |
| Other bias | Unclear risk | funding not reported |