Table 1.
Effect of vitamin D3 on adipogenesis of in vitro
| Author (year) | Cell type | Conclusion made |
|---|---|---|
| Basoli et al. (2017)24 | Adipose-derived stem cells | Inhibited adipogenesis: suppression of specific adipogenesis orchestrating genes |
| Chang and Kim (2016)25 | 3T3-L1 | Decreased adipocyte lipid storage: increased NAD-SIRT1 pathway |
| Ricciardi et al. (2015)26 | Immortalized brown fat cell line | Suppressed differentiation: suppression of Pparg |
| Sakuma et al. (2012)27 | 3T3-L1 | Inhibited adipocyte differentiation: suppression of Pparg and Cebpa, Erk and maintenance of WNT/β-catenin pathway |
| Sun and Zemel (2008)28 | 3T3-L1 | Inhibited adipogenesis: liganded nVDR with 1,25(OH)2D |
| Cianferotti and Demay (2007)29 | Murine bone marrow stromal cells | Inhibited adipogenesis: suppression of Dkk1 and Sfrp2 (inhibitors of the canonical WNT signaling pathway) |
| Zhuang et al. (2007)20 | Porcine preadipocyte | Inhibited adipogenesis: suppression of Pparg and interfered with the induction of Rxra |
| Kong and Li (2006)30 | 3T3-L1 | Inhibited adipogenesis: decreased expression of Cebpa and via acting as a Pparg antagonist |
| Duque et al. (2004)23 | Mice bone marrow cells | Inhibited adipogenesis |
| Huang et al. (2002)31 | Rat adipocyte | Inhibits glucose uptake by adipocytes |
| Shi et al. (2002)32 | Human adipocytes | Inhibited adipogenesis: suppression of UCP2 expression |
| Kelly and Gimble (1998)33 | Murine bone marrow stromal cell (BMS2) | Inhibited adipocyte differentiation: decreased late adipocyte gene markers, Ap2 and adipsin |
WNT, wingless-type MMTV integration site; nVDR, nuclear vitamin D receptor; 1,25(OH)2D, 1,25-dihydroxyvitamin D; UCP2, uncoupling protein 2.