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. Author manuscript; available in PMC: 2019 May 13.
Published in final edited form as: Nat Genet. 2018 Jul 16;50(8):1081–1085. doi: 10.1038/s41588-018-0168-y

Figure 1. Regional association plot of chromosome 1q32.2 demonstrating a pharmacogenomic association between rs2205986 and IFN-β-induced liver injury.

Figure 1

The interferon regulatory factor 6 (IRF6) gene is located ~132-kb upstream of synaptotagmin 14 (SYT14). Association results [primary y-axis, -log10(P-value)] are shown for genetic variants along with recombination rates (secondary y-axis, cM/Mb) for a 1.5 Mb region on chromosome 1. Each circle represents the -log10(P-value) from the logistic regression analysis, adjusted for MS disease course in the stage one case-control cohort (n=151). Genetic variants are coloured according to their pairwise correlation (r2) with rs2205986 (purple circle) using linkage disequilibrium data from the 1000 Genomes Project (European population). Three genes (MIR4260, TRAF3IP3, C1orf74) were omitted from the figure due to space requirements.