Table 2:
Association analysis of rs2205986 genotype on peak biochemical liver tests results during IFN-β treatment in multiple sclerosis patients from the Vanderbilt University Medical Center (VUMC) repository, BioVU, USA
| Biochemical Liver Test | Measurement | aBeta coefficient | P-valuea | First recorded value (mean) | Highest recorded value (mean) | Mean highest value by genotype (GG / GA / AA) |
|---|---|---|---|---|---|---|
| ALP | Units/L | 52.28 | 4.9 × 10−4 | 79 | 101 | 255 / 140 / 94 |
| Upper limit of normal | 0.35 | 5.0 × 10−4 | NA | NA | NA | |
| AST | Units/L | 29.39 | 7.6 × 10−5 | 29 | 42 | 147 / 59 / 38 |
| Upper limit of normal | 0.73 | 7.6 × 10−5 | NA | NA | NA | |
| ALT | Units/L | 5.29 | 0.54 | 34 | 47 | 112 / 43 / 47 |
| Upper limit of normal | 0.10 | 0.54 | NA | NA | NA | |
| TBIL | mg/dL | 0.00 | 0.98 | 0.49 | 0.77 | 1.00 / 0.59 / 0.77 |
| Upper limit of normal | 0.00 | 0.98 | NA | NA | NA |
a
Linear regressions using additive genetic model for highest values, adjusted for age at biochemical liver test date, sex, and the first two principal components in n=87 MS patients exposed to interferon-beta. ALP, alkaline phosphatase; ALT; alanine transaminase; AST, aspartate aminotransferase; TBIL, total bilirubin, NA: Not applicable.