Database	Time span	Search strategy
The Cochrane Hepato‐Biliary Controlled Trials Register	Date will be given at review stage.	(sophor* or ku shen or kushen or matrine or oxymatrine or kujin) AND ((hepatitis B or hep B or hbv) and chronic)
Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library	Latest issue	(sophor* or ku shen or kushen or matrine or oxymatrine or kujin) AND CENTRAL:TARGET MESH DESCRIPTOR Hepatitis B, Chronic EXPLODE ALL AND CENTRAL:TARGET ((hepatitis B or hep B or hbv) and chronic) AND CENTRAL:TARGET #2 OR #3 #1 AND #4
MEDLINE Ovid	1946 to the date of search	1. (sophor* or ku shen or kushen or matrine or oxymatrine or kujin).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms] 2. exp Hepatitis B, Chronic/ 3. ((hepatitis B or hep B or hbv) and chronic).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms] 4. 2 or 3 5. 1 and 4
Embase Ovid	1974 to the date of search	1. (sophor* or ku shen or kushen or matrine or oxymatrine or kujin).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading word] 2. exp chronic hepatitis B/ 3. ((hepatitis B or hep B or hbv) and chronic).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading word] 4. 2 or 3 5. 1 and 4
LILACS (Bireme)	1982 to the date of search	(sophor$ or ku shen or kushen or matrine or oxymatrine or kujin) [Words] and ((hepatitis B or hep B or hbv) and chronic) [Words]
Science Citation Index Expanded (Web of Science)	1900 to the date of search	#3 #2 AND #1 #2 TS=((hepatitis B or hep B or hbv) and chronic) #1 TS=(sophor* or ku shen or kushen or matrine or oxymatrine or kujin)
Conference Proceedings Citation Index – Science (Web of Science)	1990 to the date of search	#3 #2 AND #1 #2 TS=((hepatitis B or hep B or hbv) and chronic) #1 TS=(sophor* or ku shen or kushen or matrine or oxymatrine or kujin)
China Network Knowledge Infrastructure (CNKI)	1994 to the date of search	Search strategy in Chinese. #1 Title/Abstract=(matrine or oxymatrine or kushen or Radix sophorae flavescentis) #2 Title/Abstract=(chronic hepatitis B) #3 Text word=(random) #4 #1 AND #2 AND #3
Chongqing VIP (CQVIP)	1989 to the date of search	Search strategy in Chinese. #1 Title/Abstract=(matrine or oxymatrine or kushen or Radix sophorae flavescentis) #2 Title/Abstract=(chronic hepatitis B) #3 Text word=(random) #4 #1 AND #2 AND #3
Wanfang	1982 to the date of search	Search strategy in Chinese. #1 Title/Abstract=(matrine or oxymatrine or kushen or Radix sophorae flavescentis) #2 Title/Abstract=(chronic hepatitis B) #3 Text word=(random) #4 #1 AND #2 AND #3
SinoMed	1978 to the date of search	Search strategy in Chinese. #1 Title/Abstract=(matrine or oxymatrine or kushen or Radix sophorae flavescentis) #2 Title/Abstract=(chronic hepatitis B) #3 Text word=(random) #4 #1 AND #2 AND #3