Comparison 20. Antacids versus prostaglandin analogues.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinically important upper GI bleeding	2	329	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.12, 0.91]
2 All‐cause mortality in ICU	2	417	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.42, 1.67]
3 Adverse events of interventions	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Diarrhoea	1	368	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.64, 1.33]
3.2 Elevated serum bicarbonate	1	338	Risk Ratio (M‐H, Fixed, 95% CI)	2.21 [1.27, 3.87]
3.3 Phospate levels < 2.5 mg/dL	1	276	Risk Ratio (M‐H, Fixed, 95% CI)	1.66 [1.01, 2.73]