IRCT201104134578N2.

Trial name or title	Ranitidine and pantoprazole in prevention of stress ulcer
Methods	Not stated
Participants	Inclusion criteria Requiring mechanical ventilation Age > 18 years Admission to the ICU APACHE score II < 25 Admission at least 24 hours in ICU Patients with suctionable secretion No GI bleeding at beginning of study Exclusion criteria History of GI bleeding Liver or kidney insufficiency History of corticosteroids or NSAID usage Gastric pH > 4 before beginning of prophylaxis
Interventions	Intervention: pantoprazole 40 mg infusion once a day until end of patient admission Control: ranitidine 50 mg infusion twice a day until end of patient admission
Outcomes	Primary outcome Gastric pH (before intervention, every 8 hours after intervention for next 2 days), measured by AZ8685 pH metery instrument Secondary outcome GI bleeding, measured by evaluating the secretion that lavaged from the patient NG tube to the end of admission in the ICU
Starting date	20 February 2011
Contact information	Farshid Rahimi Bashar, Mahdiye Street, Hamedan University Of Medical Sciences, Hamedan Iran, Islamic Republic of Telephone: 00988118276295; fr_rahimibashar@yahoo.com
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