Campos 2011.

Methods	Study design: parallel RCT Study duration: March 2008 to July 2009 Duration of follow‐up: 90 days
Participants	Setting: multicentre (3 centres) Country: not reported Patients > 18 years, had reached ESKD and required planned HD by a catheter for at least 2 weeks, had no evidence of active infection, and had discontinued any antibiotic at least 7 days before catheter implantation; only catheters implanted in jugular and subclavian veins Number: 150 patients; treatment group (102 catheters); control group (102 catheters) Mean age ± SD (years): treatment group (54.56 ± 16.86); control group (55.55 ± 15.35) Sex (M): treatment group (62%); control group (53.7%) Exclusion criteria: in the first two sessions of HD, the catheter did not allow a pump blood flow rate of > 200 mL/min for non‐tunnelled catheters and > 250 mL/min for tunnelled catheters; protocol violation
Interventions	Treatment group Minocycline: 3 mg/mL EDTA: 30 mg/mL Control group Heparin: 5000 U/mL
Outcomes	CRI Catheter dysfunction
Notes	Funding source: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Study was described as randomised, method of randomisation was not reported
Allocation concealment (selection bias)	Unclear risk	Allocation was performed by sealed envelope, but did not state if they were opaque
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patient outcome data was reported
Selective reporting (reporting bias)	Low risk	Describes the outcome according to protocol
Other bias	Unclear risk	Funding source not reported