Cooper 1999.

Methods	Study design: parallel RCT Study duration: not reported Duration of follow‐up: not reported
Participants	Setting: not reported Country: USA Chronic HD patients with permanent HD catheter access Number: treatment group (19); control group (17) Mean age ± SD (years): not reported Sex (M/F): not reported Exclusion criteria: not reported
Interventions	Treatment group Gentamicin: 40 mg/lumen Control group Heparin: 5000 U/lumen
Outcomes	CRI: diagnosed by positive blood cultures with no other identifiable infection source Probable CRI: diagnostic when clinical suspicion of infection was high but blood cultures were negative
Notes	Abstract‐only publication Funding source: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement
Other bias	Unclear risk	Insufficient information to permit judgement