D'Avella 2007.

Methods	Study design: parallel RCT Study duration: not reported Duration of follow‐up: not reported
Participants	Setting: single centre Country: USA Chronic HD patients with permanent catheter Number: treatment group (46); control group (45) Mean age ± SD (years): not reported Sex (M/F): not reported Exclusion criteria: not reported
Interventions	Treatment group Saline: 18% Heparin: 7000 U/mL Control group Saline: 0.9% Heparin: 10,000 U/mL
Outcomes	CRI
Notes	Abstract‐only publication Funding source: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement
Other bias	Unclear risk	Insufficient information to permit judgement