Hendrickx 2001.

Methods	Study design: parallel RCT Study duration: April to October 2000 Duration of follow‐up: not reported
Participants	Setting: single centre Country: Belgium Patients with a single lumen CVC as permanent access Number: treatment group (10); control group (9) Mean age (years): treatment group (74.6); control group (71.4) Sex (M/F): treatment group (4/6); control group (4/5) Exclusion criteria: temporary catheter; previous history of catheter position‐related inadequate blood flow; known history of haemorrhagic diathesis or systemic thrombo‐embolic events; liver failure; on chronic anticoagulation therapy (low dose aspirin excluded)
Interventions	Treatment group Trisodium citrate: 5% Control group Heparin: 5000 U/mL
Outcomes	Non‐occlusive clot formation Complete occlusion of the catheter Necessity for urokinase therapy Incidence of flow problems CRI.
Notes	Most of the outcome were not defined Funding source: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Study was described as randomised, method of randomisation was not reported "...patients were randomly assigned..."
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patient outcome data reported
Selective reporting (reporting bias)	Low risk	Describes the outcome according to protocol
Other bias	Unclear risk	Funding source not reported