McIntyre 2004.

Methods	Study design: parallel RCT Study duration: March 2002 to April 2003 Duration of follow‐up: not reported
Participants	Setting: single centre Country: UK Participants to have had no evidence of CRI, having been antibiotic free for at least 28 days before catheter insertion Number (participants/catheters): treatment group (25/25); control group (25/25) Mean age ± SD (years): treatment group (63.6 ± 2.8); control group (57.8 ± 3.2) Sex (M/F): treatment group (18/7); control group (14/11) Exclusion criteria: catheter was an exchange reinsertion; insertion at a separate site (with previous catheter still in situ); recent infection; those on immunosuppressant medications
Interventions	Treatment group Gentamicin: 5 mg/mL Heparin: 5000 IU/mL. Control group Heparin: 5000 U/mL
Outcomes	CRI Catheter malfunction
Notes	Funding source: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	The study was block randomised; method of randomisation not reported
Allocation concealment (selection bias)	Unclear risk	Randomisation was performed by sealed envelope, but not opaque
Blinding of participants and personnel (performance bias) All outcomes	High risk	By the characteristics of the solution used, blinding of intervention was not possible
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	All analyses were performed on an intention‐to‐treat basis
Selective reporting (reporting bias)	Low risk	Describes the outcome according to protocol
Other bias	Unclear risk	Insufficient information to permit judgement