Nori 2006.

Methods	Study design: parallel RCT Study duration: 4 October 2003 and 30 April 2004 Duration of follow‐up: not reported
Participants	Setting: multicentre (3) Country: USA Participants with either tunnelled or non tunnelled (only if placed in the internal jugular vein) catheter as their primary vascular access Number (randomised/analysed/catheters): treatment group 1 (20/20/20); treatment group 2 (21/21/21); control group (21/20/21) Mean age ± SEM (years): treatment group 1 (58 ± 3);treatment group 2 (58 ± 3) control group (59 ± 4) Sex (M/F): treatment group 1 (11/9); treatment group 2 (13/8); control group (10/10) Exclusion criteria: < 18 years; required a surrogate decision maker; antibiotic treatment within 2 weeks before the date of enrolment; catheters with blood flow rates < 300 mL/min; required frequent thrombolytic solution dwells in the catheter lumen for malfunction; admitted to an outside hospital for any illness; required thrombolytics for catheter thromboses on more than 3 occasions
Interventions	Treatment group 1 Gentamicin: 4 mg/mL Citrate: 3.13 % Treatment group 1 Minocycline: 3 mg/mL EDTA: 30 mg/mL Control group Heparin: 5000 U/mL
Outcomes	CRI
Notes	Funding source: None
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Permuted block randomisation was performed at each centre; method not reported
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patient data reported
Selective reporting (reporting bias)	Low risk	Describes the outcomes according to objectives
Other bias	Unclear risk	Insufficient information to permit judgement