Pervez 2002.

Methods	Study design: parallel RCT Study duration: January 1999 to April 2000 Duration of follow‐up: not reported
Participants	Setting: single centre Country: USA Participants who underwent tunnelled catheter placement, including participants who had a tunnelled catheter changed over guide wire Number (participants/catheters): treatment group (14/14); control group (22/22) Mean age ± SE (years): treatment group I (53.7 ± 4.0); control group (47.6 ± 3.3) Sex (M/F): treatment group I (10/4); control group (10/12) Exclusion criteria: not reported
Interventions	Treatment group Tricitrasol: 46:7% Gentamicin: 40 mg/mL Control group Heparin: 1000 U/mL
Outcomes	CRI
Notes	Catheter hub covered with a sterile plastic bag after cleaning with a 10% povidone iodine solution Funding source: "This study was supported by the Dialysis Clinic Inc."
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Use computer‐generated number list
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patient data reported
Selective reporting (reporting bias)	Low risk	Describes the outcome according to objective
Other bias	Unclear risk	Was supported by the Dialysis Clinic Inc