Saxena 2006.

Methods	Study design: RCT Study duration: March 2002 to February 2003 Duration of follow‐up: 18 months
Participants	Setting: single centre Country: Saudi Arabia Elderly participants who underwent reinsertion of a tunnelled central catheter through a new access site Number (randomised/analysed/catheters): treatment group (60/59/61); control group (58/55/63) Mean age ± SD (years): treatment group (78 ± 19); control group (75.5 ± 17) Sex (M/F): Treatment group (36/22); control group (32/23) Exclusion criteria: active sepsis, receiving prolonged (> 7 days) antibiotic therapy (oral/parenteral); allergies to cephalosporins; could not be randomised within 3 dialysis sessions of new tunnel catheter insertion; had the exchange over guidewires of a tunnelled catheter through the same exit site were also excluded
Interventions	Treatment group Cefotaxime: 10 mg/mL Heparin: 5000 U/mL Control group Heparin: 5000 U/mL
Outcomes	CRI Thrombosis
Notes	Funding source: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Use computer‐generated random number list
Allocation concealment (selection bias)	Low risk	Numbered, opaque, sealed envelopes
Blinding of participants and personnel (performance bias) All outcomes	Low risk	The patient's and HD staff were blinded of the treatment assigned
Blinding of outcome assessment (detection bias) All outcomes	Low risk	The microbiologist was blinded of the treatment assigned
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Low risk	Describes the outcome according to objective
Other bias	Unclear risk	Insufficient information to permit judgement