Saxena 2012.

Methods	Study design: RCT Study duration: April 2005 to March 2006 Duration of follow‐up: not reported
Participants	Setting: multicentre (2) Country: Saudi Arabia Participants > 18 years carrying S. aureus that would require the installation of a tunnelled central catheter for HD start or maintenance Number (participants/catheters): treatment group (39/41); control group (43/47) Mean age ± SD (years): treatment group (53.7 ± 17.2); control group (51.9 ± 19.1) Sex (M/F): treatment group (23/16); control group (26/17) Exclusion criteria: active sepsis receiving prolonged antibiotic therapy; hypersensitivity to heparin or cephalosporins; catheter exchanged over a guidewire; existing exit‐site or tunnel infection; pregnant women
Interventions	Treatment group Cefotaxime: 10 mg/mL Heparin: 5000 U/mL Control group Heparin: 5000 U/mL
Outcomes	CRI Death related to CRI Exit site infection
Notes	Funding source: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated random number
Allocation concealment (selection bias)	Low risk	Sealed, opaque envelopes, numbered in sequence
Blinding of participants and personnel (performance bias) All outcomes	Low risk	The pharmacy dispensed equal number of identical syringes
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Microbiologist was blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patient outcome data reported
Selective reporting (reporting bias)	Low risk	Describes the outcome according to protocol
Other bias	Unclear risk	Insufficient information to permit judgement