Shirzad 2013.

Methods	Study design: parallel RCT Study duration: not reported Duration of follow‐up: not reported
Participants	Setting: single centre Country: Iran Participants who underwent reinsertion of a tunnelled central catheter through a new access site Number (participants/catheters): treatment group (58/59); control group (55/60) Mean age ± SD (years): treatment group (78 ± 19); control group (75.5 ± 17) Sex (M/F): treatment group (36/22); control group (32/23) Exclusion criteria: active sepsis, receiving prolonged (> 7 days) antibiotic therapy (oral/parenteral) or allergies to cephalosporins; who could not be randomised within 3 dialysis sessions of new catheter insertion; catheter exchange over guidewires through the same exit site
Interventions	Treatment group Cefazolin: 5 mg/dL Heparin: 2500 IU Control group Heparin: 2500 IU
Outcomes	Infection
Notes	Funding source: not reported Translated from Persian
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement
Other bias	Unclear risk	Insufficient information to permit judgement