| Methods |
Study design: parallel RCT Study duration: December 2004 and June 2008 Duration of follow‐up: not reported |
| Participants |
Setting: single centre Country: Greece Participants required a temporary non‐tunnelled catheter for commencement or maintenance of HD on the basis of ESKD Number (participants/catheters): 135/156; treatment group 1 (not reported/49); treatment group 2 (not reported/52); control group (not reported/51) Mean age, range (years): treatment group 1 (72, 62 to 80); treatment group 2 (67.5, 47 to 75); control group (72, 65 to 77) Sex (males): treatment group 1 (30); treatment group 2 (28); control group (33) Exclusion criteria: active systemic or localized infection under antibiotic treatment; sepsis; allergy to heparin, vancomycin or linezolid; heparin‐induced thrombocytopenia and thrombosis mediated by antiheparin antibodies; pregnancy; catheter was used for any other reason than for HD; AKI requiring HD use of immunosuppressive drugs; diagnosis of a current malignancy |
| Interventions |
Treatment group 1
Treatment group 2
Control group
|
| Outcomes |
CRI CRI‐free survival Exit site infections Bacterial colonisation Thrombosis |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Table of random numbers |
| Allocation concealment (selection bias) |
Unclear risk |
Insufficient information to permit judgement |
| Blinding of participants and personnel (performance bias)
All outcomes |
Unclear risk |
Insufficient information to permit judgement |
| Blinding of outcome assessment (detection bias)
All outcomes |
Unclear risk |
Insufficient information to permit judgement |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
No missing outcome data |
| Selective reporting (reporting bias) |
Low risk |
Describes the outcome according to protocol |
| Other bias |
Unclear risk |
Insufficient information to permit judgement |
