Solomon 2010.

Methods	Study design: parallel RCT Study duration: not reported Duration of follow‐up: not reported
Participants	Setting: multicentre (13 centres) Country: UK Participants aged > 18 years receiving tunnelled intravascular catheters for HD and able to give informed consent Number (randomised/analysed/catheters): treatment group (55/53/56); control group (55/54/58) Mean age ± SD (years): treatment group (59.8 ± 14.7); control group (56.7 ± 17.4) Sex (M/F): treatment group (26/27); control group (41/13) Exclusion criteria: not reported
Interventions	Treatment group Taurolidine: 1.35% Citrate: 4% Control group Heparin: 5000 U/mL
Outcomes	Bacteraemia Thrombosis (defined by need for thrombolytic therapy) All‐cause mortality
Notes	Funding source: "This work was supported in part by a grant from the Preston branch of the North West Kidney Research Association and a grant from the Liverpool Regional Dialysis Unit Fund."
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Use computer‐generated randomised permuted blocks of 10 participants stratified among the 3 main centres
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Low risk	All study personnel and participants were blinded to treatment assignment
Blinding of outcome assessment (detection bias) All outcomes	Low risk	All study personnel and participants were blinded to treatment assignment
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Low risk	Describes the outcome according to objective
Other bias	Unclear risk	Insufficient information to permit judgement