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. 2018 Apr 3;2018(4):CD010597. doi: 10.1002/14651858.CD010597.pub2

Zwiech 2016a.

Methods

  • Study design: parallel RCT

  • Study duration: not reported

  • Duration of follow‐up: not reported
Participants

  • Setting: single centre

  • Country: Poland

  • Participants on chronic HD, fitted with a permanent HD catheter for < 3 months or a newly implanted non‐tunnelled or tunnelled catheter for continuing HD treatment

  • Participants (randomised/analysed): treatment group (29/28); control group (24/24)

  • Mean age SD (years): treatment group: (57.11 ± 14.46); control group (56.24 ± 11.98)

  • Sex (M/F): treatment group (14/12); control group (11/13)

  • Exclusion criteria: antibiotic treatment in the previous 4 weeks; presence of any infections during the study period needing antibiotic treatment; S. aureus in a nasal swab
Interventions Treatment group

  • Tauloridine: 1.35%

  • Citrate: 4%

  • Heparin: 500 IU


Control group

  • Heparin: 5000 IU/mL
Outcomes

  • CRI
Notes

  • Study in two phases. Phase 1 is included in the present review

  • Funding source: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Use computer‐generated random number list
Allocation concealment (selection bias) Unclear risk Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Insufficient information to permit judgement
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No missing outcome data
Selective reporting (reporting bias) Low risk Describes the outcome according to protocol
Other bias Unclear risk Insufficient information to permit judgement

AKI ‐ acute kidney injury; AV ‐ arteriovenous; CFU ‐ colony‐forming units; CKD ‐ chronic kidney disease; CRI ‐ catheter‐related infection; CRS ‐ catheter‐related sepsis; CVC ‐ central venous catheter; ESKD ‐ end‐stage kidney disease; HD ‐ haemodialysis; ICU ‐ intensive care unit; IV ‐ intravenous; M/F ‐ male/female; RCT ‐ randomised controlled trial; SD ‐ standard deviation