CLOCK 2017.

Methods	Study design: parallel RCT Study duration: March 2014 to November 2016 Duration of follow‐up: 100 days
Participants	Setting: single centre Country: Brazil Participants aged between 18 to 75 years and with a CKD 5D diagnosis; on high efficiency HD and long‐term CVC for HD, with a subclavian insertion on either the right and left sides Number: treatment group 1 (25); treatment group 2 (25); control group (25) Mean age ± SD (years): treatment group 1 (53.3 ± 15.5); treatment group 2 (55 ± 13); control group (53.2 ± 15.5) Sex (M/F): treatment group 1 (12/13); treatment group 2 (12/13); control group (12/13) Exclusion criteria: pregnant females; on oral anticoagulant treatment; signs of subclinical or active infection; poor catheter care
Interventions	Treatment group 1 Trisodium citrate: 30% Treatment group 2 M‐EDTA Control group Heparin: 1000 IU/mL
Outcomes	Increased hydraulic resistance CRI Infection (clinical signs and laboratory findings) Adverse drug reactions
Notes	Funding source: "We also thank the following institutions for grants: University of Sao Paulo, Conselho Nacional de Desenvolvimento Cientıfico e Tecnol ogico (CNPq), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)."

CKD ‐ chronic kidney disease; CRI ‐ catheter‐related infection; CVC ‐ central venous catheter; HD ‐ haemodialysis; M/F ‐ male/female; RCT ‐ randomised controlled trial; SD ‐ standard deviation