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. 2018 Aug 20;2018(8):CD012274. doi: 10.1002/14651858.CD012274.pub2

Comparison 1. Continued versus discontinued oxytocin stimulation in the active phase.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Caesarean delivery 9 1784 Risk Ratio (M‐H, Fixed, 95% CI) 0.69 [0.56, 0.86]
2 Duration of the active phase of labour 8 1336 Mean Difference (IV, Random, 95% CI) 25.57 [5.28, 45.87]
3 Postpartum haemorrhage of 500 mL or more 5 996 Risk Ratio (M‐H, Fixed, 95% CI) 0.72 [0.45, 1.13]
4 Uterine tachysystole combined with abnormal fetal heart rate 3 486 Risk Ratio (M‐H, Fixed, 95% CI) 0.15 [0.05, 0.46]
5 Uterine tachysystole 4 728 Risk Ratio (M‐H, Fixed, 95% CI) 0.45 [0.30, 0.68]
6 Chorioamnionitis 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 2.32 [0.99, 5.45]
7 Use of analgesia and epidural during labour 3 556 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.95, 1.14]
8 Third‐ and fourth‐degree perineal tear 1 199 Risk Ratio (M‐H, Fixed, 95% CI) 0.25 [0.03, 2.22]
9 Vaginal instrumental delivery 5 848 Risk Ratio (M‐H, Fixed, 95% CI) 1.07 [0.67, 1.72]
10 Caesarean delivery after the active phase of labour has begun 4 898 Risk Ratio (M‐H, Fixed, 95% CI) 0.87 [0.62, 1.23]
11 Caesarean delivery after active phase begun using "reached active phase" as denominator 4 787 Risk Ratio (M‐H, Fixed, 95% CI) 0.92 [0.65, 1.29]
12 Intrapartum cardiotocography (CTG) abnormalities (suspicious/pathological CTGs) 7 1390 Risk Ratio (M‐H, Fixed, 95% CI) 0.65 [0.51, 0.83]
13 Apgar score at five minutes below seven 4 893 Risk Ratio (M‐H, Fixed, 95% CI) 0.78 [0.27, 2.21]
14 Acidotic cord gasses at birth (arterial umbilical pH < 7.10) 4 873 Risk Ratio (M‐H, Fixed, 95% CI) 1.03 [0.50, 2.13]
15 Neonatal admission to the neonatal intensive care unit 6 1434 Risk Ratio (M‐H, Fixed, 95% CI) 0.75 [0.49, 1.13]