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. 2014 Jun 13;2014(6):CD001338. doi: 10.1002/14651858.CD001338.pub3

Comparison 5. Oral misoprostol versus vaginal PG (2): all women.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Vaginal delivery not achieved within 24 hours 5 2128 Risk Ratio (M‐H, Fixed, 95% CI) 1.10 [0.99, 1.22]
1.1 25 mcg 4 1928 Risk Ratio (M‐H, Fixed, 95% CI) 1.11 [0.99, 1.25]
1.2 50 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.3 100 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 1.03 [0.83, 1.29]
2 Uterine hyperstimulation with FHR changes 7 2352 Risk Ratio (M‐H, Fixed, 95% CI) 0.95 [0.59, 1.53]
2.1 25 mcg 4 1827 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.51, 1.41]
2.2 50 mcg 2 325 Risk Ratio (M‐H, Fixed, 95% CI) 1.52 [0.26, 9.01]
2.3 100 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 5.0 [0.24, 102.85]
3 Caesarean section 10 3240 Risk Ratio (M‐H, Fixed, 95% CI) 0.92 [0.81, 1.04]
3.1 25 mcg 6 2355 Risk Ratio (M‐H, Fixed, 95% CI) 0.87 [0.75, 1.01]
3.2 50 mcg 3 685 Risk Ratio (M‐H, Fixed, 95% CI) 1.06 [0.83, 1.35]
3.3 100 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 0.93 [0.58, 1.48]
4 Serious neonatal morbidity or perinatal death 1 741 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.1 25 mcg 1 741 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.2 50 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 Serious maternal morbidity or death 2 1436 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.1 25 mcg 2 1436 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.2 50 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Cervix unfavourable/unchanged after 12‐24 hours 2 930 Risk Ratio (M‐H, Fixed, 95% CI) 1.41 [1.01, 1.96]
6.1 25 mcg 2 930 Risk Ratio (M‐H, Fixed, 95% CI) 1.41 [1.01, 1.96]
6.2 50 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 Oxytocin augmentation 7   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
7.1 25 mcg 3 1239 Risk Ratio (M‐H, Random, 95% CI) 0.97 [0.73, 1.30]
7.2 50 mcg 3 685 Risk Ratio (M‐H, Random, 95% CI) 1.28 [0.97, 1.69]
7.3 100 mcg 1 200 Risk Ratio (M‐H, Random, 95% CI) 1.28 [0.98, 1.66]
8 Uterine hyperstimulation without FHR changes 8   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
8.1 25 mcg 5 2123 Risk Ratio (M‐H, Random, 95% CI) 0.81 [0.32, 2.03]
8.2 50 mcg 2 325 Risk Ratio (M‐H, Random, 95% CI) 0.71 [0.29, 1.76]
8.3 100 mcg 1 200 Risk Ratio (M‐H, Random, 95% CI) 7.0 [0.37, 133.78]
9 Ruptured uterus 7 2757 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
9.1 25 mcg 5 2130 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
9.2 50 mcg 2 627 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
10 Epidural analgesia 2 799 Risk Ratio (M‐H, Fixed, 95% CI) 1.08 [0.98, 1.19]
10.1 25 mcg 1 741 Risk Ratio (M‐H, Fixed, 95% CI) 1.09 [0.98, 1.22]
10.2 50 mcg 1 58 Risk Ratio (M‐H, Fixed, 95% CI) 0.95 [0.76, 1.18]
11 Instrumental vaginal delivery 6 2524 Risk Ratio (M‐H, Fixed, 95% CI) 1.05 [0.88, 1.24]
11.1 25 mcg 4 1857 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.83, 1.30]
11.2 50 mcg 2 467 Risk Ratio (M‐H, Fixed, 95% CI) 1.03 [0.73, 1.45]
11.3 100 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 1.12 [0.71, 1.75]
12 Meconium‐stained liquor 8 2548 Risk Ratio (M‐H, Fixed, 95% CI) 1.07 [0.86, 1.32]
12.1 25 mcg 4 1463 Risk Ratio (M‐H, Fixed, 95% CI) 1.17 [0.89, 1.54]
12.2 50 mcg 4 885 Risk Ratio (M‐H, Fixed, 95% CI) 0.98 [0.67, 1.44]
12.3 100 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 0.81 [0.41, 1.60]
13 Apgar score < 7 at 5 minutes 6 2181 Risk Ratio (M‐H, Fixed, 95% CI) 0.59 [0.32, 1.10]
13.1 25 mcg 4 1856 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.35, 1.25]
13.2 50 mcg 2 325 Risk Ratio (M‐H, Fixed, 95% CI) 0.24 [0.03, 2.16]
14 Neonatal intensive care unit admission 9 3181 Risk Ratio (M‐H, Fixed, 95% CI) 0.79 [0.59, 1.05]
14.1 25 mcg 6 2354 Risk Ratio (M‐H, Fixed, 95% CI) 0.79 [0.57, 1.10]
14.2 50 mcg 2 627 Risk Ratio (M‐H, Fixed, 95% CI) 0.54 [0.19, 1.53]
14.3 100 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.47, 2.12]
15 Neonatal encephalopathy 2 1101 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
15.1 25 mcg 1 741 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
15.2 50 mcg 1 360 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
16 Perinatal death 4 1899 Risk Ratio (M‐H, Fixed, 95% CI) 1.00 [0.06, 15.97]
16.1 25 mcg 3 1632 Risk Ratio (M‐H, Fixed, 95% CI) 1.00 [0.06, 15.97]
16.2 50 mcg 1 267 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
17 Maternal side effects (all) 3 1632 Risk Ratio (M‐H, Random, 95% CI) 1.03 [0.77, 1.36]
17.1 25 mcg 3 1632 Risk Ratio (M‐H, Random, 95% CI) 1.03 [0.77, 1.36]
17.2 50 mcg 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
18 Nausea 3 1023 Risk Ratio (M‐H, Fixed, 95% CI) 0.70 [0.44, 1.11]
18.1 25 mcg 2 965 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.41, 1.07]
18.2 50 mcg 1 58 Risk Ratio (M‐H, Fixed, 95% CI) 2.14 [0.21, 22.35]
19 Vomiting 3 1632 Risk Ratio (M‐H, Fixed, 95% CI) 1.11 [0.79, 1.54]
19.1 25 mcg 2 1432 Risk Ratio (M‐H, Fixed, 95% CI) 1.05 [0.71, 1.56]
19.2 50 mcg 1 200 Risk Ratio (M‐H, Fixed, 95% CI) 1.27 [0.68, 2.35]
20 Diarrhoea 2 965 Risk Ratio (M‐H, Fixed, 95% CI) 0.72 [0.27, 1.87]
20.1 25 mcg 2 965 Risk Ratio (M‐H, Fixed, 95% CI) 0.72 [0.27, 1.87]
20.2 50 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
21 Shivering 2 891 Risk Ratio (M‐H, Fixed, 95% CI) 1.05 [0.81, 1.37]
21.1 25 mcg 2 891 Risk Ratio (M‐H, Fixed, 95% CI) 1.05 [0.81, 1.37]
21.2 50 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
22 Postpartum haemorrhage 3 1633 Risk Ratio (M‐H, Fixed, 95% CI) 0.90 [0.74, 1.11]
22.1 25 mcg 3 1633 Risk Ratio (M‐H, Fixed, 95% CI) 0.90 [0.74, 1.11]
22.2 50 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
23 Serious maternal complications 1 692 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
23.1 25 mcg 1 692 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
23.2 50 mcg 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
24 Hyperpyrexia 2 965 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
24.1 25 mcg 2 965 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]