Comparison 35. Oral misoprostol 3/4‐hourly versus 6‐hourly (10): all women.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Uterine hyperstimulation with FHR changes	2	222	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.07, 4.30]
1.1 50mcg	1	89	Risk Ratio (M‐H, Random, 95% CI)	0.18 [0.02, 1.42]
1.2 100mcg	1	133	Risk Ratio (M‐H, Random, 95% CI)	1.43 [0.25, 8.31]
2 Caesarean section	2	222	Risk Ratio (M‐H, Fixed, 95% CI)	1.41 [0.71, 2.80]
2.1 50 mcg	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	1.60 [0.49, 5.30]
2.2 100mcg	1	133	Risk Ratio (M‐H, Fixed, 95% CI)	1.31 [0.56, 3.06]
3 Oxytocin augmentation	2	222	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.63, 1.07]
3.1 50mcg	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.63, 2.08]
3.2 100mcg	1	133	Risk Ratio (M‐H, Fixed, 95% CI)	0.72 [0.54, 0.96]
4 Uterine hyperstimulation without FHR changes	1	133	Risk Ratio (M‐H, Fixed, 95% CI)	1.43 [0.25, 8.31]
4.1 100mcg	1	133	Risk Ratio (M‐H, Fixed, 95% CI)	1.43 [0.25, 8.31]
5 Instrumental vaginal delivery	2	222	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.23, 1.61]
5.1 50mcg	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.16, 2.53]
5.2 100mcg	1	133	Risk Ratio (M‐H, Fixed, 95% CI)	0.57 [0.14, 2.30]
6 Meconium‐stained liquor	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	3.20 [0.13, 76.60]
6.1 50mcg	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	3.20 [0.13, 76.60]
7 Nausea	2	222	Risk Ratio (M‐H, Fixed, 95% CI)	0.23 [0.04, 1.31]
7.1 50mcg	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.01, 8.51]
7.2 100mcg	1	133	Risk Ratio (M‐H, Fixed, 95% CI)	0.19 [0.02, 1.59]
8 Diarrhoea	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.01, 8.51]
8.1 50mcg	1	89	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.01, 8.51]