Hofmeyr 2001(T).

Methods	Sequentially‐numbered, opaque envelopes.
Participants	695 women in whom the decision has been made to induce labour with dinoprostone regardless of membrane and cervical status. Women with previous CS, twins and breech presentation were excluded.
Interventions	Titrated oral misoprostol versus vaginal dinoprostone 2 mg. Oral misoprostol was administered as solution (200 mcg tablet dissolved in 200 mL of water). Initial 2‐3 doses were 20 mcg increased to 40 mcg every 2 hours. Further doses were not given if contractions were judged to be clinically adequate. Vaginal dinoprostone was given as a 2 mg gel followed by another dose 6 hours later. In both groups oxytocin was started if there was no response after 24 hours.
Outcomes	Labour and birth outcomes. Neonatal outcomes. Maternal side effects.
Notes	5 women lost to follow‐up.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Envelopes were prepared using a computer‐ generated list of allocation. Allocations were balanced between groups using random block size (Betwwen two and six).
Allocation concealment (selection bias)	Low risk	Sequentially‐numbered, opaque envelopes.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to permit judgement of ‘Low risk’ or ‘High risk’
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement of ‘Low risk’ or ‘High risk’
Other bias	Unclear risk	Insufficient information to permit judgement of ‘Low risk’ or ‘High risk’
Blinding of participants and personnel (performance bias) All outcomes	High risk	The study was not blinded.
Blinding of outcome assessment (detection bias) All outcomes	High risk	The study was not blinded.