Pandian 2009.

Methods	Design: RCT Recruitment method: all women presenting with vaginal bleeding up to 16 weeks of pregnancy were assessed for inclusion Method of randomisation: sealed envelopes picked by the participants Setting: Department of Obstetrics and Gynaecology, Seberang Jaya Hospital
Participants	Inclusion: women with threatened abortion. Viability of fetus confirmed by U/S. no systematic illness or fever and no loss of conception tissue Exclusion: women with recurrent miscarriage (> 3), heavy bleeding, cervical polyp, multiple gestation, empty sac > 26 mm Particpants randomised: 191 women
Interventions	Intervention group: (96 women) 40 mg followed by 10 mg twice daily Control group: (95 women) conservative treatment with bed rest only
Outcomes	Miscarriage rate Placenta previa Preterm delivery Congenital anomalies APH Caesarean section Low birth weight Preganancy induced hypertension Perinatal death
Notes	Journal: Maturitas Year of publication: 2009 Country: Malaysia Income status of the country: upper middle‐income Source of funding: Solvay Pharmaceutical Company Conflict of interest: no conflicts
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random allocation of each women using sealed envelope
Allocation concealment (selection bias)	Low risk	Concealed envelope
Blinding of participants and personnel (performance bias) All outcomes	High risk	Participants and the study personnel were not blinded
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Only the statistician was blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	There was no loss of follow‐up
Selective reporting (reporting bias)	Low risk	All the prespecified outcomes were addressed
Other bias	Low risk	No apparent other sources of bias