Comparison 2. Antibiotics versus placebo in acute rhinosinusitis: secondary outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Severity or duration of different clinical symptoms: resolution of purulent secretion	3	660	Odds Ratio (M‐H, Fixed, 95% CI)	1.58 [1.13, 2.22]
2 Side effects: total	10	1816	Odds Ratio (M‐H, Fixed, 95% CI)	2.21 [1.74, 2.82]
2.1 Clinically diagnosed rhinosinusitis	7	1371	Odds Ratio (M‐H, Fixed, 95% CI)	2.10 [1.60, 2.77]
2.2 Rhinosinusitis confirmed by imaging	3	445	Odds Ratio (M‐H, Fixed, 95% CI)	2.65 [1.58, 4.46]
3 Side effects: diarrhoea	7	1210	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.00 [1.41, 2.85]
4 Clinical failure	12	2603	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.48 [0.36, 0.63]
4.1 Clinically diagnosed rhinosinusitis	8	2101	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.49 [0.36, 0.67]
4.2 Rhinosinusitis confirmed by radiography	2	312	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.09 [0.52, 8.35]
4.3 Rhinosinusitis confirmed by computed tomography	2	190	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.25 [0.11, 0.55]