Comparison 3. Sensitivity analyses.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinically diagnosed rhinosinusitis	9	19409	Odds Ratio (M‐H, Fixed, 95% CI)	1.22 [1.14, 1.29]
1.1 Cure at 1 week	4	856	Odds Ratio (M‐H, Fixed, 95% CI)	1.07 [0.81, 1.41]
1.2 Cure at 10 days	4	1048	Odds Ratio (M‐H, Fixed, 95% CI)	1.19 [0.92, 1.53]
1.3 Cure at 2 weeks	4	717	Odds Ratio (M‐H, Fixed, 95% CI)	1.37 [0.98, 1.91]
1.4 Cure at 1 week, with Garbutt data	5	1011	Odds Ratio (M‐H, Fixed, 95% CI)	1.20 [0.93, 1.54]
1.5 Cure at 10 days, with Garbutt data	5	1203	Odds Ratio (M‐H, Fixed, 95% CI)	1.16 [0.91, 1.47]
1.6 Influence of missing data: cure at any time point if dropouts were successes	8	1785	Odds Ratio (M‐H, Fixed, 95% CI)	1.24 [1.02, 1.52]
1.7 Influence of missing data: cure at any time point if dropouts were failures	8	1785	Odds Ratio (M‐H, Fixed, 95% CI)	1.24 [1.02, 1.51]
1.8 Influence of missing data: cure at any time point if dropouts had the same cure rate as control group	8	1785	Odds Ratio (M‐H, Fixed, 95% CI)	1.24 [1.02, 1.51]
1.9 Influence of missing data: cure at 1 week if dropouts were successes	4	901	Odds Ratio (M‐H, Fixed, 95% CI)	1.03 [0.79, 1.35]
1.10 Influence of missing data: cure at 1 week if dropouts were failures	4	901	Odds Ratio (M‐H, Fixed, 95% CI)	1.10 [0.84, 1.44]
1.11 Influence of missing data: cure at 1 week if dropouts had the same cure rate as control group	3	632	Odds Ratio (M‐H, Fixed, 95% CI)	1.09 [0.79, 1.50]
1.12 Influence of missing data: cure at 10 days if dropouts were successes	3	840	Odds Ratio (M‐H, Fixed, 95% CI)	1.25 [0.94, 1.66]
1.13 Influence of missing data: cure at 10 days if dropouts were failures	3	840	Odds Ratio (M‐H, Fixed, 95% CI)	1.25 [0.94, 1.65]
1.14 Influence of missing data: cure at 10 days if dropouts had the same cure rate as control group	3	840	Odds Ratio (M‐H, Fixed, 95% CI)	1.24 [0.93, 1.65]
1.15 Influence of missing data: cure at 2 weeks if dropouts were successes	4	1026	Odds Ratio (M‐H, Fixed, 95% CI)	1.30 [0.98, 1.73]
1.16 Influence of missing data: cure at 2 weeks if dropouts were failures	4	776	Odds Ratio (M‐H, Fixed, 95% CI)	1.35 [0.99, 1.84]
1.17 Influence of missing data: cure at 2 weeks if dropouts had the same cure rate as control group	4	776	Odds Ratio (M‐H, Fixed, 95% CI)	1.35 [0.99, 1.86]
1.18 Overall treatment effect (with Young 2008 data concerning Stalman)	8	1687	Odds Ratio (M‐H, Fixed, 95% CI)	1.27 [1.04, 1.56]
2 Rhinosinusitis confirmed by imaging	5	1086	Odds Ratio (M‐H, Fixed, 95% CI)	1.85 [1.41, 2.44]
2.1 Cure at any time point	5	584	Odds Ratio (M‐H, Fixed, 95% CI)	1.71 [1.20, 2.45]
2.2 Cure or improvement at any time point	4	502	Odds Ratio (M‐H, Fixed, 95% CI)	2.08 [1.35, 3.21]