2. Summary of disease severity score results.
| Ref ID | Instrument details |
How reported (time point) |
Results |
Difference between groups Notes |
|
| Antifungal | Placebo | ||||
| Topical antifungals | |||||
| Ebbens 2006 | RSOM‐31 Range: 0 to 775a Lower score = better QOL |
Change from baseline (13 weeks) |
Baseline: 150 Mean change: 17.0 SD: 86.4 N: 59 |
Baseline: 176 Mean change: ‐3.6 SD: 100.4 N: 57 |
P = 0.35 Small relative changes (17 and 3.6 points on a scale of 0 to 775) |
| Hashemian 2016 | SNOT‐20 Range: 0 to 100 Lower score = better QOL |
Endpoint (8 weeks) |
Baseline: 36.29 After treatment: 27.25 SD: 15.88 N: 24 |
Baseline: 41.33 After treatment: 28.71 SD: 18.24 N: 24 |
P = 0.76 Large SD values compared to mean may be an indication that the data are skewed |
| Liang 2008 | Chinese RSOM‐31 Range: 0 to 775a Lower score = better QOL |
Endpoint (4 weeks) |
Median baseline: 201.5 Median after treatment: 65.5 Range: 10 to 466 N: 32 |
Median baseline: 227 Median after treatment: 121.5 Range: 8 to 405 N: 32 |
P = 0.091 Unequal distribution of median within the range values indicate the data are likely to be skewed |
| Ponikau 2005 | SNOT‐20 Range: 0 to 5 Lower score = better QOL |
Change from baseline (6 months) |
Median baseline: 2.3 Median change: ‐0.3 Range: ‐1.3 to 0.3 N: 10 |
Median baseline: 1.8 Median change: ‐0.3 Range: ‐1.8 to 0.8 N: 14 |
P = 0.72 Data reported as medians and ranges indicating possibility of skewed data, although the median appears to sit in middle of range values |
| Systemic antifungals | |||||
| Kennedy 2005 | Rhinosinusitis Disability Index (RSDI) Range: 0 to 120 Lower score = better QOL |
Unclear (9 weeks) |
Values for the results were not given | Authors state that "no differences were observed” at any time point measured | |
IQR: interquartile ranges; N: number of participants; QOL: quality of life; RSOM‐31: Rhinosinusitis Outcome Measure‐31; SD: standard deviation; SNOT‐20: Sino‐Nasal Outcome Test‐20
a) The range is not explicitly stated in the paper but is assumed to be from 0 to 775, which is the general range for the RSOM‐31 instrument including the importance scale. b) The range is not explicitly stated in the paper but is the standard range for the RSDI instrument.