Comparison 1. Topical antifungal versus placebo/no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Generic HRQL (change from baseline)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 Physical component	1	116	Mean Difference (IV, Fixed, 95% CI)	‐0.80 [‐3.66, 2.06]
1.2 Mental component	1	116	Mean Difference (IV, Fixed, 95% CI)	‐2.20 [‐5.46, 1.06]
2 Adverse effects ‐ epistaxis	4	225	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.14, 6.63]
3 Adverse effects ‐ headache	3	195	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [0.60, 2.63]
4 Adverse effects ‐ local irritation	5	312	Risk Ratio (M‐H, Fixed, 95% CI)	2.29 [0.61, 8.62]
5 CT score	1	48	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.22 [‐0.79, 0.34]