Comparison 2. Systemic antifungal versus placebo/no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Severe adverse effects ‐ hepatic toxicity	1	53	Risk Ratio (M‐H, Fixed, 95% CI)	3.35 [0.14, 78.60]
2 Adverse effects ‐ gastrointestinal disturbances	1	53	Risk Ratio (M‐H, Fixed, 95% CI)	0.37 [0.04, 3.36]
3 CT score ‐ opacification % change from baseline	1	49	Mean Difference (IV, Fixed, 95% CI)	‐0.14 [‐19.22, 18.94]
4 CT score ‐ obstruction score % change from baseline	1	47	Mean Difference (IV, Fixed, 95% CI)	‐4.4 [‐40.12, 31.32]