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. 2018 Jul 5;2018(7):CD011849. doi: 10.1002/14651858.CD011849.pub2

Bolton 2007.

Methods RCT
Participants Acholi adolescents 14 to 17 years of age, living in 2 camps for internally displaced persons near Gulu, Uganda. The war in Northern Uganda represents one of the most violent and persistent complex humanitarian emergencies in the world. Over 1.8 million individuals, mainly ethnic Acholi, have been internally displaced during 20 years of conflict between the government of Uganda and the Lord's Resistance Army. Eligible participants scored greater than 32 on the depression symptom scale and greater than 0 on the function scale; had symptoms for at least 1 month; and resided in the camps during the preceding month. Exclusion criteria were inability to be interviewed due to a cognitive or physical disability and severe suicidal ideation or behaviour
Interventions Group interpersonal psychotherapy (IPT‐G): 105 participants
Wait list: 104 participants
Creative play (CP): 105 participants
Outcomes Depressive symptoms; anxiety symptoms; conduct problems; functioning. Recovery, defined as a reduction of 50% or more of an individual's baseline symptom severity score; remission, defined as at or less than a predefined cutoff score of 15.6 points (mean score of non‐cases in the validation study)
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "Random allocation was done by computerized generation of a random number between 1 and 400 for each eligible participant, ordering them by number and assigning the first third to IPT‐G, the second third to CP and the final third to the wait‐control group"
Allocation concealment (selection bias) Unclear risk No information provided
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Quote: "Informed consent included advising each youth of the study group to which he or she had been allocated"
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Quote: "Interviewers were blinded to interviewees’ intervention status"
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Dropouts reported at study endpoint (17/105 missing from creative play group; 9/105 missing from interpersonal psychotherapy group; 16/104 missing from control group)
Selective reporting (reporting bias) Low risk All outcomes are correctly reported
Therapist qualification Unclear risk Interventions were delivered by trained facilitators
Treatment fidelity Unclear risk Quote: "IPT supervisors also provided weekly written reports that were reviewed and discussed with study staff during the phone meetings for adherence to the treatment model and to monitor human subject protection"
Therapist/investigator allegiance High risk Manualised IPT was developed in the United States, and study authors were involved in training facilitators
Other bias Unclear risk No information provided