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. 2015 Oct 15;2015(10):CD007753. doi: 10.1002/14651858.CD007753.pub3

Chen 2008.

Study characteristics
Methods RCT, 3 arms
Participants 66 participants with cancer pain randomised to 3 groups: 'mild pain', 'moderate pain' and 'severe pain'
Each of these 3 pain groups randomly divided into an acupuncture group and an oral medication group
Interventions Group 1: acupuncture
Group 2: oral medication group according to WHO 3 step administration in which participants in:
  • mild pain were given aspirin

  • moderate pain were given codeine

  • severe pain were given morphine

Outcomes Pain scores measured on a VAS, with response percentage calculated as [(score before‐score after)/score before] x 100
Analgesic effect reported from percentage difference in pain score. Complete relief (CR) 91%‐100%, average relief (AR) 61%‐90%, partial relief (PR) 31%‐60%, or no relief (NR) > 31%
Notes Translated from Chinese
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomisation tables used to allocate subjects to the acupuncture or medication groups. It was not clear whether randomisation was carried out by blinded personnel
Allocation concealment (selection bias) Unclear risk Allocation concealment was not clearly stated
Blinding (performance bias and detection bias)
All outcomes High risk Participant and evaluator blinding not described
Incomplete outcome data (attrition bias)
All outcomes High risk Incomplete data and withdrawals not described
Other bias High risk Poor reporting of intervention and methodology
Inadequate statistical analysis
Sample size High risk 66 participants randomly allocated to 3 groups of 22