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. 2018 Jul 31;2018(7):CD007859. doi: 10.1002/14651858.CD007859.pub4

Summary of findings 3. Conventional nickel‐titanium (NiTi) versus superelastic NiTi arch wires.

Conventional NiTi versus superelastic NiTi arch wires
Population: people receiving orthodontic treatment with fixed appliances
 Settings: university clinics, faculty practices and private practices
 Intervention: superelastic NiTi
Control: conventional NiTi
Outcomes Illustrative comparative risks* (95% CI) Relative effect
 (95% CI) Number of participants
 (studies) Quality of the evidence
 (GRADE) Comments
Assumed risk Corresponding risk
Control Superelastic NiTi
Alignment rate between canines
 Little's Irregularity Index
 Follow‐up: about 5 weeks Mean alignment rate in the control groups was
 1.42 mm/about 5 weeks
(1.34 mm per month)
Mean alignment rate between canines in the intervention groups was
 0.28 faster
 (0.33 slower to 0.89 faster)   40
 (1 study) ⊕⊝⊝⊝
 very low1,2 Abdelrahman 2015a also reported no statistically significant difference of alignment rate over 8 or 16 weeks.
Time to alignment
 Follow‐up: 16 weeks Mean time to alignment in the control groups was
 9.8 weeks Mean time to alignment in the intervention groups was
 0.3 longer
 (1.14 shorter to 1.74 longer)   49
 (1 study) ⊕⊕⊝⊝
 low2  
Pain day 1
 VAS (0‐100 mm)
 Follow‐up: 7 days Mean pain in the control groups was
 37.8 Mean pain day 1 in the intervention groups was
 1.1 mm lower
 (15.1 lower to 12.9 higher)   79
 (1 study) ⊕⊝⊝⊝
 very low1,2 MD of pain day 7 (multistrand stainless steel versus superelastic NiTi) was ‐0.40, 95% CI ‐4.61 to 3.81
RR of analgesic consumption within 7 days (multistrand stainless steel versus superelastic NiTi) was 2.58, 95% CI 0.52 to 12.81
Root resorption Not measured
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 CI: confidence interval; MD: mean difference; NiTi: nickel‐titanium; RR: risk ratio
GRADE Working Group grades of evidence
 High quality: we are very confident that the true effect lies close to that of the estimate of the effect.
 Moderate quality: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
 Low quality: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
 Very low quality: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

1Downgraded one level due to serious risk of bias: one study at high risk.
 2Downgraded two levels due to very serious imprecision.