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. 2018 Jul 31;2018(7):CD007859. doi: 10.1002/14651858.CD007859.pub4

Summary of findings 4. Conventional nickel‐titanium (NiTi) versus thermoelastic NiTi arch wires.

Conventional NiTi versus thermoelastic NiTi arch wires
Population: people receiving orthodontic treatment with fixed appliances
 Settings: university clinics, faculty practices and private practices
 Intervention: thermoelastic NiTi
Control: conventional NiTi
Outcomes Illustrative comparative risks* (95% CI) Relative effect
 (95% CI) Number of participants
 (studies) Quality of the evidence
 (GRADE) Comments
Assumed risk Corresponding risk
Control Thermoelastic NiTi
Alignment rate ratio (hazard ratio of Kaplan‐Meier survival estimates)
 Follow‐up: 6 months   Alignment rate ratio (thermoelastic: conventional) was 1.3
(0.68 to 2.50)
HR 1.3
(0.68 to 2.50)
60
(1 study)
⊕⊕⊝⊝
 low1 Abdelrahman 2015a also reported no statistically significant difference of alignment rate over 8 or 16 weeks.
Time to alignment
 Follow‐up: 16 weeks Mean time to alignment in the control groups was
 9.8 weeks Mean time to alignment in the intervention groups was 0.2 shorter
 (1.64 shorter to 1.24 longer)   49
 (1 study) ⊕⊕⊝⊝
 low1  
Pain Not measured
Root resorption Not measured
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 CI: confidence interval; HR: hazard ratio; NiTi: nickel‐titanium
GRADE Working Group grades of evidence
 High quality: we are very confident that the true effect lies close to that of the estimate of the effect.
 Moderate quality: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
 Low quality: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
 Very low quality: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

1Downgraded two levels due to very serious imprecision.