Summary of findings 3. NPWT 75 mmHg compared with standard care in other open traumatic wounds.
| NPWT 75 mmHg compared with standard care in other open traumatic wounds | ||||||
| Patient or population: other open traumatic wounds Setting: rabies clinic Intervention: NPWT 75 mmHg Comparison: standard care | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with standard care | Risk with NPWT 75 mmHg | |||||
| Complete wound healing | Not estimable | Not estimable | Not estimable | Not estimable | Not estimable | ‐ |
|
Wound infection Follow‐up: unclear |
90 per 1000 | 39 per 1000 (15 to 99) | RR 0.44 (0.17 to 1.10) | 463 (1 study) | ⊕⊝⊝⊝ Very low1 |
It is uncertain whether there are differences in incidence of infection between the intervention groups. |
| Adverse events | Not estimable | Not estimable | Not estimable | Not estimable | Not estimable | ‐ |
| Time to closure or coverage surgery | Not estimable | Not estimable | Not estimable | Not estimable | Not estimable | ‐ |
| Pain | Not estimable | Not estimable | Not estimable | Not estimable | Not estimable | ‐ |
| *The risk in the intervention group (and its 95% confidence interval) is based on the median risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect | ||||||
1Downgraded three levels: risk of bias (no blind outcome assessment); very serious imprecision due to small sample size and wide confidence interval.