Name of outcome	1. Certainty of evidence	2. Starting score for certainty of evidence according to study design	3. Criteria to downgrade score
			3a. Study limitation	3b. Indirectness of evidence	3c. Inconsistency	3d. Imprecision	3e. Publication bias
Comparison 1: Interventions targeting patients compared with usual care
OBOM ‐ Continuous	1	4	‐2	‐1	‐2	‐2	N/A
PROM ‐ Continuous	1	4	‐2	‐1	‐2	0	0
PROM ‐ Continuous ‐ (Non‐randomized control trial)	1	2	‐2	‐1	N/A	‐1	N/A
PROM ‐ Categorical	1	4	‐2	‐1	‐1	0	0
Comparison 2: Interventions targeting healthcare professionals compared to usual care
OBOM ‐ Continuous	1	4	‐1	‐1	‐2	‐1	0
OBOM ‐ Continuous ‐ (Controlled before‐after study)	1	2	‐2	‐1	N/A	‐1	N/A
PROM ‐ Continuous	1	4	‐1	‐1	‐2	‐1	0
PROM ‐ Categorical	1	4	‐1	‐1	‐2	0	N/A
Comparison 3: Interventions targeting both patients and healthcare professionals compared to usual care
OBOM ‐ Continuous	1	4	‐1	‐1	‐2	‐1	‐1
PROM ‐ Continuous	1	4	‐1	‐1	‐1	0	0
PROM ‐ Categorical	1	4	‐1	‐1	‐1	‐1	N/A
Comparison 4: Interventions targeting patients compared to other interventions targeting patients
OBOM ‐ Continuous	1	4	‐1	‐1	‐2	‐1	N/A
PROM ‐ Continuous	1	4	‐1	‐1	‐2	‐1	0
PROM ‐ Continuous ‐ (Non‐randomized control trial)	1	2	‐2	‐1	N/A	‐1	N/A
PROM ‐ Categorical	1	4	‐2	‐1	‐1	0	0
Comparison 5: Interventions targeting healthcare professionals compared to other interventions targeting healthcare professionals
OBOM ‐ Continuous	1	4	0	‐1	N/A	‐2	N/A
PROM ‐ Continuous	1	4	‐1	‐1	‐2	‐1	N/A
Comparison 6: Interventions targeting both patients and healthcare professionals compared to other interventions targeting both patients and healthcare professionals
OBOM ‐ Continuous	1	4	‐1	‐1	N/A	‐1	N/A
OBOM ‐ Categorial	1	4	‐2	‐1	N/A	‐1	N/A
PROM ‐ Continuous	1	4	‐1	‐1	N/A	‐1	N/A