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. 2018 Jul 19;2018(7):CD006732. doi: 10.1002/14651858.CD006732.pub4

Bieber 2006.

Methods Study design: patient‐randomized trial
Unit of allocation: patient
Unit of analysis: patient
Power calculation: not clear
Participants Care setting: specialized care and ambulatory care (Rheumatologic Outpatient Clinic of the University of Heidelberg); Germany
 Health professionals: 10; internal medicine; fully trained
Patients: 149; fibromyalgia syndrome; male and female
Interventions Multifaceted intervention: educational meeting with physician (18 hours); patient‐mediated intervention (computer‐based visualized information tool).
The computer‐based tool provided information on fibromyalgia syndrome, combining textual information with diagrams and short video sequences. The educational meeting involved training physicians to improve patient‐centered communication and interaction skills.
Single intervention (control): patient‐mediated intervention (computer‐based visualized information tool)
The tool was the same as the multifaceted intervention.
Outcomes Doctor‐patient interaction, from the patient perspective, using the QQPPI (Questionnaire on the Quality of Physician‐Patient Interaction) (continuous); joint process between healthcare professionals and patients to make decisions.
Notes Additional information
Number of approached patients (eligible): not reported
Number of patients per physician: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: patients were randomized but the method was unspecified.
Allocation concealment (selection bias) Unclear risk Comment: not specified in the paper.
Blinding (performance bias and detection bias) 
 Participant‐reported outcome Low risk Quote: "Patients were informed on the intervention but they were blinded to the fact in which group they were being treated." Page 359
Incomplete outcome data (attrition bias) 
 Participant‐reported outcome Unclear risk Comment: 64/149 (43%) patients were excluded after randomization (did not meet inclusion criteria, refused to complete questionnaire); Information about missing data in our primary outcome were lacking.
Selective reporting (reporting bias) Unclear risk Comment: no evidence that outcomes were selectively reported, but no protocol.
Other bias Low risk Comment: no evidence of other risk of biases.
Baseline measurement? 
 Participant‐reported outcome Unclear risk Comment: baseline measurements for the FAPI are not reported, nor were they measured.
Protection against contamination? High risk Comment: it was the patients who were randomized in an university outpatient setting.
Baseline characteristics patients Low risk Quote: "All three patient group were comparable as to socio‐economic (see Table 1) and health related variables (see Table 3)." page 359
Baseline characteristics healthcare professionals Unclear risk Comment: no report of characteristics.