Date	Event	Description
28 June 2018	New citation required and conclusions have changed	The inclusion of two trials in a previously empty review has enabled us to revise our earlier conclusions.
28 June 2018	New search has been performed	A search of the Group's Cystic Fibrosis Register identified nine new references (Frederiksen 2006, Singh 2013, Sharma 2016, Khorasani 2009, Flume 2015, Hodges 2014; Muhlebach 2017; Neri 2016). Two trials were eligible for inclusion (Neri 2016; Muhlebach 2017). One article reports the data from a recently completed study identified in a previous version of this review (Muhlebach 2017). A search of PubMed and MEDLINE identified a further four trials, none of which were not eligible and are listed under 'Excluded studies' (Bittencourt 2016; Hall 2015; Kappler 2016; Vallieres 2016). A search of two ongoing trials registers (www.clinicaltrials.gov; www.isrctn.org) identified one new trial, which is not eligible for inclusion in the review (NCT03181932). Two of the ongoing trials identified in the previous version of this review are now listed as completed ‐ NCT01349192 (Muhlebach 2017) and NCT01746095 (Dasenbrook 2015). Data from one of these are included in this review (Muhlebach 2017), but currently the only published data identified from the Dasenbrook trial has been in abstract form only and does not provide sufficient information to assess eligibility for inclusion (Dasenbrook 2015). Therefore this trial is currently listed under "Studies awaiting classification". The third previously identified ongoing trial is still ongoing but no longer recruiting participants (Dasenbrook 2012). At this update a summary of findings table has been added to the review.