Theodorakopoulou 2016.

Methods	Study design: prospective, randomized controlled trial Study dates: period of one year, but study dates not available Setting: single centre. ICU at Attikon University Hospital. Athens. Greece
Participants	Inclusion criteria Mechanically‐ventilated septic participants Exclusion criteria Obese patients Sample size Total number of participants enrolled: 74 Age (years): whole group age of 68.4 ± 18.4 years Sex (male, %): 38 men included (100%) Primary disease of the participants: all participants met the consensus criteria for sepsis. Disease severity score: at entry overall APACHE II score 22 ± 4. etc. and SOFA score 8 ± 4 Mechanical ventilation: 100% of the participants were mechanically ventilated Comorbidities: not reported Nutrition status: non‐obese participants. Overall BMI ≈ 21.5 ± 3.4 kg/m2
Interventions	Permisive underfeeding group (n = not available ) Caloric goal 50% to 70% of calculated caloric requirements. During the study period the participants received 962 ± 314 kcal/day or 51 ± 14% of the caloric requirements, and 57 ± 24 grams protein day. Standar protocol feeding group (n = not available) 80% to 100% of calculated caloric requirement. During the study period the participants received 1308 ± 513 kcal/day or 82 ± 14% of the caloric requirements, and 59 ± 25 grams of protein day. Same protein intake for both groups: 1.5 gr protein/kg/day Each participant monitored for 14 days
Outcomes	Primary outcome 28‐day mortality
Funding sources	Not available.
Declarations of interest	Not available
Notes	This information was extracted from an abstract. We contacted Dr. Maria Theodorakoupoulou to request the missing data (including outcome data).
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information for judgement (abstract only)
Allocation concealment (selection bias)	Unclear risk	Insufficient information for judgement (abstract only)
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information for judgement (abstract only)
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information for judgement (abstract only)
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information for judgement (abstract only)
Selective reporting (reporting bias)	Unclear risk	Insufficient information for judgement (abstract only)
Other bias	Unclear risk	Insufficient information for judgement (abstract only)

Abbreviations:

APACHE = acute physiology and chronic health evaluation; BMI = Body Mass Index ; CD = cluster of differentiation; CIT = conventional insulin therapy; dl = decilitre; EN = enteral nutrition; gr = gram; GRV = gastric residual volumes; hr = hour; ICU = intensive care unit; IIT = intensive insulin therapy; IVFE = Intravenous fat emulsion; kcal = kilocalories; kg = kilograms; mg = milligrams; NHLBI = National Heart, Lung, and Blood Institute; NNIS = National Nosocomial Infection Surveillance; OMEGA = OMEGA study (Rauch 2010); PN = parenteral nutrition; SD = standard deviation; SOFA = sequential organ failure assessment; TPN = total parenteral nutrition; UAB = unassisted breathing; VFD = ventilator‐free days