Domchek 2006.

Methods	Prospective cohort study, matching design
Participants	Country: multicountry: University of Vienna, Austria; Creighton University, Omaha, NE, USA; Dana‐Farber Cancer Institute, Boston, MA, USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Georgetown University, Washington, DC, USA; University of Chicago, Chicago, IL, USA; University of Pennsylvania, Philadelphia, PA, USA; University of Utah, Salt Lake City, UT, USA; Netherlands Cancer Institute, Amsterdam, Netherlands; Royal Marsden Hospital, Sutton, UK; St Mary’s Hospital, Manchester, UK; University of Texas‐Southwestern, Dallas, TX, USA and Yale University, New Haven, CT, USA Enrolled: 155 surgical participants and 271 control participants Women with BRCA1 or BRCA2 mutation carriers
Interventions	Arm A: RRSO Arm B: general surveillance or non‐RRSO
Outcomes	Overall survival Ovarian cancer mortality Primary peritoneal cancer mortality Breast cancer mortality Ovarian cancer incidence Breast cancer incidence Primary peritoneal cancer incidence
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	See Table 7