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. 2018 Aug 24;2018(8):CD012464. doi: 10.1002/14651858.CD012464.pub2

Heemskerk‐Gerritsen 2015a.

Methods Partly retrospective and prospective cohort study, matching design
Participants Country: Netherlands
Enrolled: 146 surgical participants and 576 control participants
Women with BRCA1 or BRCA2 mutation carriers
Interventions Arm A: RRSO
Arm B: general surveillance or non‐RRSO
Outcomes Ovarian cancer mortality
Breast cancer mortality
Ovarian cancer incidence
Breast cancer incidence
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk See Table 7