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. 2018 Jul 18;2018(7):CD003177. doi: 10.1002/14651858.CD003177.pub3
Methods RCT, parallel (n‐3 EPA + DHA vs unclear), 12 months
Summary risk of bias: moderate to high
Participants People with successful external cardioversion
N: unclear intervention, unclear control (54 analysed intervention, 54 control)
Level of risk for CVD: high
Men: 70% intervention, 74% control
Mean age in years (SD): 65.0 (mean for whole group, SD not reported)
Age range: not reported
Smokers: not reported
Hypertension: not reported
Medications taken by at least 50% of those in the control group: not reported
Medications taken by 20%‐49% of those in the control group: not reported
Medications taken by some, but less than 20% of the control group: not reported
Location: Germany
Ethnicity: not reported
Interventions Type: supplement (probably, not described)
Comparison: high EPA + DHA vs unclear placebo
Intervention: described only as "PUFA" but included in systematic review (Mariani 2013) by Erdogan et al on effects of n‐3 PUFA. Dose: unclear
Control: described only as "placebo"
Compliance: not reported
Length of intervention: 12 months
Outcomes Main study outcome: atrial fibrillation relapse
Dropouts: not reported
Available outcomes: recurrent AF (reported in Mariani 2013), mortality (none)
Response to contact: no reply to date
Notes Funding source: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "randomly assigned"
Allocation concealment (selection bias) Unclear risk Not described
Blinding of participants and personnel (performance bias) All outcomes Unclear risk Described as triple blind, but no further details provided (only an abstract with some details in a related trial publication and some in a systematic review by the same author)
Blinding of outcome assessment (detection bias) All outcomes Unclear risk Not described, but analysis appears to have been carried out blind to intervention/control status
Incomplete outcome data (attrition bias) All outcomes Unclear risk Number randomised not described
Selective reporting (reporting bias) Unclear risk Unclear, no trial registry entry or protocol found
Attention Unclear risk Not described
Compliance Unclear risk Not described
Other bias Low risk None noted