Comparison 3. First‐line ACE inhibitor vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total mortality	3	6002	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.72, 0.95]
2 Total stroke	3	6002	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.52, 0.82]
3 Total coronary heart disease	2	5145	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.70, 0.94]
4 Total cardiovascular events	2	5145	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.67, 0.85]
5 Systolic blood pressure	2	1071	Mean Difference (IV, Fixed, 99% CI)	‐21.14 [‐23.13, ‐19.15]
6 Diastolic blood pressure	2	1071	Mean Difference (IV, Fixed, 99% CI)	‐9.64 [‐10.70, ‐8.58]