Comparison 4. First‐line calcium channel blocker vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total mortality	1	4695	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.68, 1.09]
2 Total stroke	1	4695	Risk Ratio (M‐H, Fixed, 95% CI)	0.58 [0.41, 0.84]
3 Total coronary heart disease	1	4695	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.55, 1.09]
4 Total cardiovascular event	1	4695	Risk Ratio (M‐H, Fixed, 95% CI)	0.71 [0.57, 0.87]
5 Heart Failure	1	4695	Risk Ratio (M‐H, Fixed, 95% CI)	0.71 [0.45, 1.12]
6 Systolic blood pressure	1	4695	Mean Difference (IV, Fixed, 99% CI)	‐8.9 [‐10.14, ‐7.66]
7 Diastolic blood pressure	1	4695	Mean Difference (IV, Fixed, 99% CI)	‐4.5 [‐5.10, ‐3.90]