EXTRACT‐NOAC 2018.

Trial name or title	EXTRACT‐NOAC Acronym of 'Tranexamic Acid To Reduce Bleeding in Patients Treated with New Oral Anticoagulants Undergoing Dental Extraction'
Methods	Prospective, randomised, double‐blind, placebo‐controlled, multicentre, phase IV, clinical trial
Participants	People taking NOACs and undergoing tooth extractions
Interventions	To analyse whether adding TXA 10% mouthwash to standard‐of‐care procedures decreases the number of post‐extraction bleeding events in people taking NOACs. Since topical application of TXA results in minimal systemic absorption, TXA mouthwash may reduce postextraction bleeding without systemic effects. Therefore, TXA is an attractive and effective local haemostatic agent. The trial is being performed in view of drafting guidelines concerning the postoperative management of people treated with NOACs and undergoing tooth extractions. In this way, the postoperative care of this participant group can be assured and will improve
Outcomes	Post‐extraction bleeding events
Starting date	01 September 2017
Contact information	anna.ockerman@kuleuven.be
Notes	Duration 4 years

NOACs: new oral anticoagulants
 TXA: tranexamic acid